Analytics

At Sylentis, we provide comprehensive analytical support tailored to every stage of oligonucleotide development. From early-phase method development to late-phase validation and ICH stability studies, our team ensures your analytical strategy is robust, compliant, and phase-appropriate.

With deep expertise in the unique challenges of oligonucleotide analysis, we support raw materials, intermediates, and APIs. Whether developing new methods or transferring existing ones under cGMP, we help you generate high-quality data to support your CMC documentation and regulatory filings with confidence.

Our expertise

Analytical methods

UPLC (Ion-pair reverse phase)
HPLC (AEX, RP, SEC)
UV-Vis Spectroscopy
Mass Spectrometry
Karl Fischer titration
Osmolality and pH
Residual solvents (GC)
Elemental impurities (ICP-MS)
NMR
Endotoxin and bioburden testing

Analytical work packages

Method development and optimization
Method transfer and cGMP method verification
Method validation (phase-appropriate)
ICH-compliant stability studies
Impurity profiling and characterization
Batch comparisons
Raw material testing
Release testing

Our expertise

Let’s work together

Sylentis is ready to support your analytical journey. From method development to stability studies, we bring the scientific insight and regulatory know-how to help you generate reliable, phase-appropriate data—on time and with confidence.

Contact us today to explore how our analytical expertise can accelerate your development.